Ramipril and aminoguanidine restore renal lysosomal processing in streptozotocin diabetic rats
نویسندگان
چکیده
منابع مشابه
Effects of chronic ramipril treatment in streptozotocin-induced diabetic rats.
The present investigation was undertaken to study the effects of chronic oral ramipril (1 mg/kg) treatment in streptozotocin (STZ) induced diabetic rats. Single tail vein injection of STZ (45 mg/kg, i.v.) produced a diabetic state exhibiting all the cardinal symptoms such as loss of body weight, polydipsia, polyuria, glucosuria, polyphagia, hypoinsulinaemia and hyperglycaemia. The diabetic stat...
متن کاملRenal hypertrophy in streptozotocin-diabetic rats.
In male adolescent rats kidney mass attained maximum terminal value already at week 1 after streptozotocin treatment, and this value did not change over the next two weeks. At week 1 the kidney size of diabetic rats was greater than that of untreated controls, whereas at week 3 renal mass was the same in both groups. In adult rats with final body and kidney mass streptozotocin treatment failed ...
متن کاملImpaired Relaxation in Aorta from Streptozotocin-diabetic Rats: Effect of Aminoguanidine (AMNG) Treatment
AIM The effect of 8 weeks' streptozotocin (STZ)-induced diabetes and aminoguanidine (AMNG), the inhibitor of advanced glycosylation reaction, treatment on arteriolar reactivity to vasoactive substances was investigated in vitro. MATERIALS AND METHODS Studies were performed in untreated control rats (n=10), STZ-induced (60 mg/kg i.v.) diabetic rats (n=10), AMNG-treated (600mg/l given in drinki...
متن کاملPrevention of albuminuria by aminoguanidine or ramipril in streptozotocin-induced diabetic rats is associated with the normalization of glomerular protein kinase C.
This study examined whether the prevention of diabetes-related albuminuria by aminoguanidine (AG) or ramipril (RAM) may be mediated by a common post-glomerular basement membrane renal intracellular mechanism involving protein kinase C (PKC). The renal handling of albumin was examined over 24 weeks in control and streptozotocin (STZ)-induced diabetic rats. A radioimmunoassay (RIA) that measures ...
متن کاملProtective Effect of Royal Jelly against Renal Damage in Streptozotocin Induced Diabetic Rats
Background: Royal jelly has been shown to have antioxidant and antidiabetic effects. The objective of this study was to evaluate the protective effect of RJ against kidney damage in streptozotocin induced diabetic rats. Methods: Thirty two male Wistar rats were divided randomly into four groups (n=8 per group). Normal control and diabetic control groups received 1cc/day distilled water, norm...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Diabetologia
سال: 2001
ISSN: 0012-186X,1432-0428
DOI: 10.1007/s001250051604